Guest article by Mary Jo Capodice, DO, MPH, MBA, FACOEM, FAAFP, MRO for i3screen
This article is intended to educate medical professionals regarding Cannabidiol (CBD), hemp and Delta-8 tetrahydrocannabinol (delta-8) use recommendations and how the use can affect a patient’s employment.
As an Occupational Medicine physician and Medical Review Officer, on a routine day I speak to many people who have had drug screens for a variety of reasons (preemployment, random testing, post-accident, follow up, for cause, school sports and other reasons).
Years ago, a positive tetrahydrocannabinol (THC) result on a drug screen was solely due to consuming marijuana, which was illegal. Today marijuana is legal in many states. Now a positive drug screen for THC can be due to use of marijuana or due to the use of other marijuana related substances. These substances are legal in all states and sold at gas stations and other retail settings!
Federal drug testing does not recognize marijuana as legal anywhere. Federal drug testing includes DOT (FMCSA, FRA, USCG, PMHSA, FTA, FAA), military and civilian employees in safety or security sensitive positions as prescribed by the Drug Free Federal Workplace, Executive Order 12564. Medical marijuana is now legal in several states and patients are able to get medical marijuana cards from these states. Medical marijuana users will not be able to pass a federal drug screen.
For drug testing not done under the federal regulations, an employer’s policies govern what a drug screen positive for marijuana means for employment.
The most well-studied cannabinoids extracted from the cannabis plant include delta-9-tetrahydrocannabinol, or delta-9 THC, which is psychoactive. Delta-9 THC is the main cannabinoid responsible for the high associated with marijuana. Cannabidiol (CBD), in contrast, is non-psychoactive.
Marijuana and hemp are two different varieties of the cannabis plant. In the U.S., federal regulations stipulate that cannabis plants containing greater than 0.3% delta-9 THC should be classified as marijuana, while plants containing less should be classified as hemp. The marijuana grown today has high levels – from 10% to 30% – of delta-9 THC, while hemp plants contain 5% to 15% CBD.
CBD (Cannabidiol), hemp (cannabis sativa) and Delta-8 tetrahydrocannabinol products legally can contain up to 0.3% THC. These products come in varying forms: oils, creams, lotions, gummies, hookah shisha and vape pens. The THC amount is not regulated by the FDA so the amount of THC from product to product can vary. The THC in these products does not induce a “high” in the user but it does get stored in the user’s fat cells and eliminated slowly through the urine. The general public is not aware that THC is in CBD, hemp or delta-8 products.
Delta-8 THC is found in very small quantities in the cannabis plant. The delta-8 THC that is widely marketed in the U.S. is a derivative of hemp CBD.
Delta-8 THC binds to CB1 receptors less strongly than delta-9 THC, which is what makes it less psychoactive than delta-9 THC. People who seek delta-8 THC for medicinal benefits seem to prefer it over delta-9 THC because delta-8 THC does not cause them to get very high. Delta-8 THC binds to CB2 receptors with a similar strength as delta-9 THC. Delta-8 THC could potentially be preferable over delta-9 THC for treating inflammation since it is less psychoactive.
There are no published clinical studies thus far on whether delta-8 THC can be used to treat clinical disorders, such as chemotherapy-induced nausea or weight loss due to HIV/AIDS, that are responsive to delta-9 THC.
At present, the drug testing laboratories cannot differentiate between THC (weed) use and THC solely from CBD, hemp or delta-8 usage in urine drug screens.
Advice for medical providers and employers
Employers should advise their existing and potential employees that CBD, hemp and delta-8 do contain THC which can affect drug screen results. These products can contain up to 0.3% THC.
Medical professionals should inquire as to a patient’s occupation and their potential to be drug screened. If the patient is in an occupation which is under the federal drug testing rules, medical marijuana, CBD, hemp and delta-8 products should not be advised for treatment. If these products are recommended for treatment, the patient should be made aware that the products can cause a positive drug test for THC.
WisMed member Dr. Mary Jo Capodice is a Medical Review Officer for i3screen, which offers technology that provides drug and alcohol testing program management, random selection and occupational health screening services.
Note: This article is intended to help medical professionals. The science in this field is always changing.
References:
U.S. Department of Transportation - DOT "CBD" Notice, National Library of Medicine - Clinicians' Guide to Cannabidiol and Hemp Oils, Mayo Clinic Proceedings - Clinicians’ Guide to Cannabidiol and Hemp Oils, American College of Clinical Pharmacology - A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential, American College of Clinical Pharmacology - A Review of Human Studies Assessing Cannabidiol's (CBD) Therapeutic Actions and Potential, Johns Hopkins Medicine - Some CBD Products May Yield Cannabis-Positive Urine Drug Tests, Harvard Health Publishing - Cannabidiol (CBD): What we know and what we don't, Journal of Analytical Toxicology - Urinary Pharmacokinetic Profile of Cannabinoids Following Administration of Vaporized and Oral Cannabidiol and Vaporized CBD-Dominant Cannabis, Centers for Disease Control and Prevention - CBD: What You Need to Know, Substance Abuse and Mental Health Services Administration - Frequently Asked Questions About Federal Workplace Drug Testing, U.S. Food and Drug Administration - 5 Things to Know about Delta-8 Tetrahydrocannabinol – Delta-8 THC, National Center for Complementary and Integrative Health - Cannabis (Marijuana) and Cannabinoids: What You Need To Know, StatPearls - Cannabinoids, Banner Health - When it comes to drug testing, CBD may not be A-OK, Medical News Today - CBD, Centers for Disease Control and Prevention - Marijuana FAQs, Healthline - What Is Pure CBD? The Best CBD Isolate Products for 2023
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